1 The reason to establish Shanghai Cord Blood Bank
Bone marrow transplantation is one of effective treatment method for leukaemia,
lymphoma, and AA etc. In China,leukaemia patient increased 40,000 cases every year.
Generally, there are 40,000-100,000 bone marrow transplantation cases every
year, but in fact, only 720 cases completed from 1984-1998, average 48 cases
per year, the most important reason for this is fewer suitable bone marrow support.
Bone marrow transplantation required that HLA 6 points matched between provider
and receiver, actually, this probability is very small, only 25% possibility
between sisters or brothers, and it's impossible to find matched HLA from
sibling due to China's one-child policy. The possibility is smaller
than one in thousands to find matched HLA from unrelated people.
Therefore, many countries established the bone marrow program. The USA
one has around 3,400,000 donors, which is the largest one in the world but
provide only one third clinical needs. The Taiwan program hass 200,000 donors that
provide 60% clinical needs, mainland China provide only 40%. Shanghai bone marrow
program only got 10,000 volunteers that provide only a few transplantations.
As the result, it is vital to find other hematopoietic stem cell except bone
marrow.
Essentially, bone marrow transplantation is the hematopoietic stem cell transplantation,
with the development of science, experts found the cord blood contained hematopoietic
stem cell. Since the first cord blood transplantation succeed in France in
1989, more than 3000 patients accepted cord blood transplantation that related
to thirty disease such as Leukaemia, ML, Neuroblasoma, AA, Mediteranean Anemia,
SCID etc.The success possibility reached to 80%. That is the reason why many
countries established cord blood bank such a high-tech biologic project.
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2 The difference between cord blood bank and Chinese marrow donor program
Bone marrow program is a data bank which keeps four of six HLA data for every donor
in data base due to financial issue. When the patient find matched four HLA
in database, the donor will be informed to take another 2 HLA test. If all
HLA matched, then the donor was ready for endow. The all process took a quite
long period; the average time is 208 days in US and 278 days in Taiwan. Some
patients missed the treatment opportunity because of deterioration during
this period or because the donor changed mind to endow. On the other hand,
the donor will lost quite often because the bone marrow program is ambulatory.
In abroad, the possibility of ambulatory is about 10%, therefore, bone marrow
program need new donor every year to maintain the quantity of donor. In addition,
the rejection of bone marrow transplantation is serious, the successful cases
is around 50% of total.
The cord blood bank is a real bank in where cord blood hematopoietic stem
cell preserved in -196°C liquid nitrogen and all HLA information is kept in
cord blood bank data base. It is convenient for patients search HLA information,
and if HLA matched, cord blood can be used immediately. Cord blood transplantation
has following advantages, cord blood has abundant source; provider has no
any pain and moral issue; searching procedure is very simple, cord blood can
be used once HLA matched; rejection of transplantation is gentle; HLA requires
only three of six matched; and infection possibility of cord blood transplantation
is few.
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3 Development of cord blood in China and in the world
In 1988, it was world-shaking that Doctor Gluckman used matched HLA to take
cord blood transplantation for Fanconi anemia patient successfully. In 1993,
New York blood center established the biggest cord blood bank in the world,
and has been preserving more than 10,000 units cord blood till now. After
that, UK, France, Germany, Italy jointly established Europe cord blood bank
that included 14 cord blood bank, preserved more than 40,000 cord blood cases
and completed transplantation for more than 1000 patients. Now in China, Beijing,
Guangzhou, Shandong, Shanghai established cord blood bank respectively and
reported the successful transplantation cases between relative people and
without blood relation people.
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4 Can cord blood transplantation be applied in adults?
There is a question that if cord blood can be applied in adult because the
one bag cord blood volume is 50ml-70ml normally. From recent clinical result,
successful transplantation possibility is 77% for over 18 years old adult,
65% for 12-17 years people, 80% for children, relative to 50% bone marrow transplantation
success possibility, cord blood transplantation can be applied for both adults
and children.
Cord blood hematopoietic stem cell transplantation increased the hematopoietic
function recovering, enhanced the success possibility of transplantation,
reduced the time patient stayed in sterile room. The cord blood transplantation
is a relative effective clinical method. On the other hand, due to the particularity
of cord blood hematopoietic stem cell, cord blood transplantation need to
be ameliorated, the study is carry through and will be applied in clinical
in the future.
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5 How about the cord blood transplantation fee
In USA, bone marrow transplantation cost about 50,000 US dollars including
30,000 researching fee and 20,000 stem cell collecting fee, plus 3,000 stem
cell transacting fee and 60,000 medicine fee (excluding operation fee and
hospital fee). Cord blood transplantation is total 31,000 US dollars, which
is the one third of bone marrow transplantation fee.
In China, cord blood transplantation cost around 350,000RMB including 10,000
researching fee, 40,000 stem cell collecting fee, and 300,000 other fee, but
it is hard to get accurate amount because there is a few without blood relation
cord blood transplantation in China. One of transplantation case expensed
only 150,000 RMB in Nanjing.
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6 The purpose of set cord blood bank and its future
The development and application of cord blood transplantation is a revolutionary
achievement that provided second life opportunity to those patients who can
not find matched stem cell. Some experts predicted that cord blood transplantation
will instead of bone marrow transplantation in the next ten years. In addition,
cord blood transplantation will be applied in other clinical field with the
deeply study.
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7 Any negative effect to lying-in women and baby when collecting cord blood
Cord blood exit in fetus's cord and has no use to the baby, collection started
after placenta was ligated, so collecting cord blood has no negative affection
to mother and baby because collection will not collection baby's blood or
mother's blood.
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8 The flow chart of cord blood collection
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9 The introduction of liquid nitrogen cryopreservation system
Liquid nitrogen cryopreservation system
BioArchive Storage System
1 two computer system: control computer and user computer
2 Liquid nitrogen dewar with storage rack that holds 3,626 25ml frozen units
3 Liquid nitrogen control module for the dewar
4 Robotic arm containing a barcode reader and periscope
5 Barcode label scanner and barcode label printer
6 Two controlled rate freezer (CRF) modules
7 One sample retrieval module
Free Consumable Supplies:
1 Canisters
2 Insulated sleeves
3 Overwrap bags
4 Processing sets
TG's BioArchive Storage System is controlled by micro-electronics processor,
a managed automatically and froze biologic products symmetrically and rapidly
aptitude system classified preserved and managed 3626/25ml cord blood, bone
marrow and other samples such as cornea, semen, blood plasma and virus samples.
TG's BioArchive Storage technology represented the world's biology technology
tide. This technology is developed by New York remark center, approved by
US FDA and NIH, the application of this system improved the efficiency for
bio-medicine study institution, hospital and bio-tech company.
Features & Benefits
Lower operating Costs: Lower Nitrogen Costs, Lower equipment costs, Lower
facility cost, Lower labor cost
Features support GMP
Integrated Controlled Rate Freezer
Molded 25ml freeze bag provides consistent sample geometry (shape, size,
volume)
Inventory management system
Robotic insertion and retrieval
Greater Safety and Security
Semi-closed system reduces operator exposure to LN2
Uninterruptible Power Source allows for completion of lacement/retrieval
in the event of power failure
24-hour surveillance and controlled access: password protected and operator
ID documented in database
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